Extracellular vesicles (EVs)

EXTRACELLULAR VESICLES

Extracellular vesicles (EVs) are nanoparticles surrounded by lipid bylayers that are released from eucaryotic and procaryotic cells. Their size ranges from 30nm to 4µm. The first evidence of these subcellular structures was found in 1956 by Don Fawcett during electron microscopic examination of tumor cells. Due to this fact and the lack of methods to analyse particles in this subcellular size range it took about five decades before their role was further investigated. Since the early 2000s, the number of publications on EVs has been increasing drastically.

Source: https://pubmed.ncbi.nlm.nih.gov/?term=extracellular+vesicle&timeline=expanded

Nanoparticle Tracking Analysis (NTA) thus contributed significantly to the understanding of the biological relevance of extracellular vesicles, as it was the first method making EVs visible in their natural dispersed state.

Using Nanoparticle Tracking Analysis and other techniques, multiple publications have shown that extracellular vesicles are involved in the regulation of cellular activities. They fulfill their functions by transporting DNA, RNA, proteins, lipids and metabolites from their origin to their target cells.

EVs are divided into exosomes, microvesicles and apoptotic bodies depending on their origin and genesis. Exosomes are the smallest EVs with a size of 30 – 130 nm. They are of endosomal origin and must undergo exocytosis to be released from their cell of origin. In addition, there are microvesicles that are up to 1000 nm in size and are formed by plasma membrane excrescence. The largest EVs are the apoptotic bodies, which are formed during programmed cell death.

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ZetaView® QUATT

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Nanoparticle Tracking Analyzer ZetaView® is a nanoparticle tracking analysis (NTA) instrument for measuring hydrodynamic particle size, zeta potential, concentration and fluorescence.

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Nanoparticle Tracking Analyzer ZetaView® is a nanoparticle tracking analysis (NTA) instrument for measuring hydrodynamic particle size, zeta potential, concentration and fluorescence.

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Nanoparticle Tracking Analyzer ZetaView® is a nanoparticle tracking analysis (NTA) instrument for measuring hydrodynamic particle size, zeta potential, concentration and fluorescence.

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